Cubs vs. Pirates prediction, betting odds for MLB on Thursday provides exclusive sports betting content to, including picks, analysis, tools and sportsbook offers to help bettors get in on the action. Please wager responsibly.

The Pittsburgh Pirates take on the Chicago Cubs in MLB at PNC Park on Thursday, beginning at 6:35 pm ET.

The Pirates will send Mitch Keller (5-11, 4.03 ERA) to the mound, up against Hayden Wesneski (1-1, 2.30 ERA) for the Cubs.

This betting analysis for Cubs vs. Pirates, which includes our best bet of the game, is brought to you by Caesars Sportsbook and powered by Dimers.

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Cubs vs. Pirates 2022

Game details

  • When: Thursday, September 22, 2022
  • Time: 6:35 pm ET
  • Where: PNC Park

Betting odds

  • Run line: Pirates -1.5 (+170), Cubs +1.5 (-200)
  • Moneyline: Pirates -120, Cubs +100
  • Total: Over/Under 7.5 (-110/-110)

Odds and lines are best available at the time of publishing and subject to change.

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Cubs vs. Pirates betting preview

Based on advanced data and computer power, Dimers has simulated Thursday’s Cubs vs. Pirates game 10,000 times.

Dimers’ independent predictive analytics model, known as DimersBOT, gives the Pirates a 55% chance of defeating the Cubs.

Elsewhere on the betting board, according to DimersBOT, the Cubs (+1.5) are a 63% chance of covering the run line. The 7.5-run Over/Under is a 52% chance of going Over.

As always, predictions and probabilities are correct at the time of publishing and subject to change.

Cubs vs. Pirates best bet

Our best bet for Cubs vs. Pirates in MLB on Thursday is Pirates moneyline (-120).

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Our betting tips are based on detailed modeling and betting intelligence to help you make more informed investments.

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Thursday’s game between the Cubs and Pirates in MLB at PNC Park is scheduled to start at 6:35 pm ET.

The Pittsburgh Pirates are a Major League Baseball team based in Pittsburgh, Pennsylvania. They compete in the National League Central division.

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